ABSTRACT
Background: Urinary tract infections (UT1s) remain the common infections inoutpatients and hospitalized patients. Recent knowledge about antimicrobialsensitivity patterns is needed for suitable treatment. The objective of this study is todetermine the changing patterns of antibiotic sensitivity in E. coli that cause UTI.
Methodology: A descriptive cross-sectional study was conducted to determine theantimicrobial susceptibility pattern of Escherichia coli in tertiary care hospital atPeshawar Pakistan. The antibiotic susceptibility pattern was determined by diskdiffusion method, according to guidelines of Clinical Laboratory Standard Institute,USA. Thirteen different common antibiotics were tested against E. coli.
Result: Out of total 143 strains, 137(95.8%) were sensitive against Imipenem,showing the highest sensitivity followed by Meropenem 134 (93.7%) andNitrofurantoine 132(92.3%). While cephradine had the lowest sensitivity 18(12.6%) followed by septran 20(14%) and Trimethoprim 20(14%). These are the highest andlowest sensitivity, recorded against E. coli. The sensitivity recorded against otherantibiotics in percentage were Gentamycin 131(91.6%), Fosfomycin 110(76.9%),Amikacin 108(75.5%), cefotaxime 22(15.4%), Augmentin 22(15.4%), Ciftazidime
31(21.9%) and Cifrofloxacin 57(39.9%).
Conclusion: We concluded from the results of this study that Imipenem (95.8%)showed the highest rate of antimicrobial sensitivity followed by Meropenem (93.7%)andNitrofurantoine (92.3%). This should be the ideal antibiotic for UTI Thesensitivity against Cephradine and Septran was not significant, as compare toImipenem.
Key words: Antibiotic sensitivity pattern, Escherichia coli, Urinary tract infection.
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