ASSOCIATION OF HYPO AND HYPERTHYROIDISM WITH LIPID PROFILE AT TERTIARY CARE HOSPITAL PESHAWAR

ABSTRACT

The thyroid is a little gland that sits in the center of the lower neck and has a butterfly-like form. Its main job is to regulate body metabolism involves controlling the pace at which cells transport substances out vital tasks for survival. The overall CVD risk is influenced by thyroid function, which has a considerable impact on lipoprotein metabolism and several risk factors for cardiovascular disease (CVD). To evaluate the association of hypo and hyperthyroidism with lipid profile and tertiary care hospital Peshawar. Objective: To determine association of hypo and hyperthyroidism with lipid profile. This study had 124 patients in total 68 of them were affected with hypothyroidism, while 24 were hyperthyroidism patients. In hypothyroidism patients, hypocholesterolaemia was 2.94% while in hyperthyroidism patients’ hypocholesterolaemia was reported to be 54 %. And with a P value of 0.017, this link was deemed to be extremely significant. In association of TSH and HDL there is significant association between TSH and HDL. In hypothyroidism patient hypolipoproteinaemia was 32%. While in hyperthyroidism patient hypolipoproteinaemia was reported to be 70% and chi-square test was conducted to assess the association of TSH and HDL level. The chi-square test was 12.485 with 4 df and the P value was 0.014. This indicates statistically significant association between TSH and HDL. This study reveals significant associations between thyroid hormones (TSH, FT3, FT4) and specific lipid levels, suggesting a potential link between thyroid function and lipid metabolism. While low TSH levels, indicative of hyperthyroidism, may be associated with alterations in lipid profiles, the direct impact on cardiovascular disease (CVD) risk remains complex and multifaceted.