Comparative Analysis Of Metoclopramide And Ondansetron In Prophylaxis Of Nausea And Vomiting For Laparoscopic Surgeries Under General Anesthesia

Abstract

Background: As limited data was founded on this topic especially in Laproscopicsurgery here is tried hard to add more information to the existing literature. Participants are selected in the study based on convenience sampling technique the two antiemetic drugs ondansetron and metoclopramide are used for postoperative nausea and vomiting prevention, two groups were selected one of them receive ondansetron and the other metoclopramide. effects of used drugs have been observed at different intervals postoperatively.

It was found that both these drugs are effective in postoperative nausea and vomiting prevention but ondansetron has been found more effective amongst the two because the group which had received ondansetron show less percent of the cases.

Aim and objective: The objective of this study is to determine which drug metoclopramide or ondansetron is more effective in managing postoperative nausea and vomiting for Laparoscopic surgery under General Anesthesia.

Methodology: Comparative cross-sectional observational study had collected at Northwest Teaching Hospital Peshawar, Pakistan, and Pak medical center & Hospital Peshawar, Pakistan. The study period was from 3rd August 2022 to 3^rd December 2022. The study includes all patients who are admitted for elective laparoscopic surgery and willing to participate, A pre-design Questionnaire was instrumented for data collection, Questionnaire had two groups. One received Ondansetron and the other group received Metoclopramide. Data about different variables were recorded and analyzed by (SPSS) version 22.

Results: Out of 104 patients in Group O 16(15.3%) were nausea +ve in the first two-hour duration (Ohr_2hr) after Laparoscopic surgery, 11(10.5%) in the second two hours (2hr 4hr) and 9(8.6%) in the third two hours (4hr 6hr) of surgery.

Vomiting was found in 11(10.5%), 6(5.7%), and 3(2.8%) patients consecutive at 2 hours interval after surgery which have been shown in the following table (1) along with Frequency, mean, and percentage for both nausea and vomiting. Group M:

In 103 patient total of 27(26.6%) were nausea +ve in the first two hour duration (Ohr_2hr) after Laparoscopic surgery, 24(23.3%) in the second two hours (2hr_4hr) and 20(19.4%) in the third two hours (4hr 6hr) of surgery

Vomiting was found in 17(16.5%), 14(13.5%), and 11(10.6%) patients consecutive at 2 hours interval after surgery which have been shown in the following table (2) along with Frequency, mean, and percentage for both nausea and vomiting.

In Group O frequency of nausea was 16 +ve in the first two-hour duration (the 2hry after Laparoscopic surgery, the frequency of nausea was 11 in the second two hours (2hr 4x) and 9 in the third two hours (4hr 6hr) of surgery Vomiting frequency was found in 11. 6 and 3 patients consecutive at 2 hours interval after surgery which have been shown in the following graph

In Group M frequency of nausea was 27 +ve in the first two-hour duration (Ohr 2hr) after Laparoscopic surgery, 24 in the second two hours (2hr 4hr), and 20 in the third two hours (4hr 6hr) of surgery. Vomiting frequency was found in 17, 14, and 11 patients consecutive at 2 hours interval after surgery which has been shown in the following graph

Conclusion:

For postoperative Nausea and Vomiting after Laparoscopic surgery under General Anesthesia Ondansetron was the best choice and also used for other Open surgeries.