Objective: To find out the estradiol to Sex Hormone Binding Globulin (SHBG) levels in polycystic ovary syndrome (PCOS) and non PCOS infertile patients.
Methodology :This was a comparative cross-sectional study. It was carried out at Jinnahabad Medical Center Abbottabad from January 2013 to July 2013. Study included 40 PCOS patients and 40 non-PCOS infertile patients. After taking informed consent and detailed history, clinical examination and ultrasound scans were performed. Blood samples were taken in early follicular phase of the menstrual cycle.
Results The data was analyzed by SPSS software version 19. SHBG was significantly decreased (p=0.008) in PCOS (32.81±32.54 nmol/L) compared to non-PCOS (40.65±21.67nmol/L). Estradiol to SHBG ratio was increased in PCOS infertile group (p=0.006, PCOS=0.03±0.025, Non-PCOS=0.013±0.011). There was no significant difference in Estradiol levels. Body Mass Index was significantly raised in PCOS patients compared to Non PCOS (p=0.001).
Conclusion SHBG levels were significantly decreased in PCOS patients while estradiol to SHBG ratio was increased in PCOS patients
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